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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
14.55
Human Site:
S332
Identified Species:
24.62
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
S332
A
G
F
I
Q
T
A
S
R
R
Q
T
F
F
D
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
S332
A
G
F
I
Q
T
A
S
R
R
Q
T
F
F
D
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
S332
A
G
F
I
E
T
A
S
R
R
Q
T
F
F
D
Dog
Lupus familis
XP_534917
565
65190
I376
G
L
P
P
T
H
F
I
Q
T
A
S
R
R
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
T443
G
L
P
P
A
H
F
T
Q
T
A
S
R
R
Q
Rat
Rattus norvegicus
Q4V8A3
586
65492
P388
L
G
C
R
Y
S
T
P
I
D
I
W
S
F
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
Y279
I
D
F
G
S
S
C
Y
E
H
Q
R
V
H
T
Chicken
Gallus gallus
Q5ZIU3
526
59419
L337
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
Frog
Xenopus laevis
Q2TAE3
750
84138
F470
Y
Y
A
L
Q
H
S
F
F
K
K
T
A
D
E
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
S440
N
D
F
V
Q
T
A
S
R
R
R
L
F
F
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
R426
K
V
L
I
S
V
A
R
R
R
R
L
F
F
D
Honey Bee
Apis mellifera
XP_396369
614
68978
N408
L
P
P
E
H
I
I
N
H
A
S
R
R
R
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
P213
S
S
E
N
V
K
L
P
D
N
K
R
S
A
A
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
G597
P
S
W
M
I
D
M
G
K
N
S
G
K
F
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
100
93.3
0
N.A.
0
13.3
N.A.
13.3
0
13.3
66.6
N.A.
46.6
0
N.A.
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
20
20
N.A.
20
6.6
46.6
80
N.A.
53.3
6.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
22
0
8
0
8
0
36
0
8
8
15
0
8
8
8
% A
% Cys:
0
0
8
0
0
8
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
15
0
0
0
8
0
0
8
8
0
0
0
8
36
% D
% Glu:
0
0
8
8
8
0
0
0
8
8
0
0
0
0
8
% E
% Phe:
0
0
36
0
0
0
15
8
8
0
0
0
36
50
0
% F
% Gly:
15
29
0
8
8
0
0
8
0
0
0
8
0
8
8
% G
% His:
0
0
0
0
8
22
0
0
8
8
0
0
0
8
0
% H
% Ile:
8
0
0
29
8
8
15
8
8
0
8
0
0
0
0
% I
% Lys:
8
0
0
0
0
8
0
0
8
8
15
0
8
0
0
% K
% Leu:
15
15
8
15
0
0
8
8
0
0
8
22
0
0
8
% L
% Met:
8
0
0
8
0
0
8
0
0
0
0
0
0
0
8
% M
% Asn:
8
0
0
8
0
0
0
8
0
15
0
0
0
0
0
% N
% Pro:
8
8
22
15
0
0
0
15
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
29
0
0
0
15
0
29
0
0
0
15
% Q
% Arg:
0
0
0
8
0
0
0
8
36
36
15
22
22
22
0
% R
% Ser:
8
15
8
0
15
15
8
29
0
0
15
15
15
0
0
% S
% Thr:
0
0
0
0
8
29
8
8
0
15
0
29
8
0
8
% T
% Val:
0
8
0
8
8
8
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
8
8
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
8
8
0
0
8
0
0
8
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _